[(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester
• CAS No.: 130534-64-4
• Molecular Formula: C₂₂H₂₈ClNO₄S₂
• Molecular Weight: 470.054
• Mol file: 130534-64-4.mol

Synonyms:[(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester

Chemical Property of [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester

There total 5 articles about [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

{3-[(2-Chloro-phenyl)-hydroxy-methyl]-5-ethyl-thiophen-2-yl}-carbamic acid tert-butyl ester (130534-62-2) + ethyl 2-sulfanylacetate (623-51-8) → [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester (130534-64-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In benzene;

DOI:10.3987/COM-90-5442

Reference yield:

2-amino-3-(2-chlorobenzoyl)-5-ethylthiophene (50508-60-6) → [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester (130534-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / NaH / dimethylformamide

2: 76 percent / NaBH₄ / dimethylformamide

3: 68 percent / PPh₃, DEAD / benzene

With sodium tetrahydroborate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; benzene;

DOI:10.3987/COM-90-5442

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid ethyl ester (130534-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / NaH / dimethylformamide

2: 76 percent / NaBH₄ / dimethylformamide

3: 68 percent / PPh₃, DEAD / benzene

With sodium tetrahydroborate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; benzene;

DOI:10.3987/COM-90-5442

upstream raw materials:

{3-[(2-Chloro-phenyl)-hydroxy-methyl]-5-ethyl-thiophen-2-yl}-carbamic acid tert-butyl ester

ethyl 2-sulfanylacetate

2-amino-3-(2-chlorobenzoyl)-5-ethylthiophene

di-tert-butyl dicarbonate

Downstream raw materials:

4-(2-Chloro-phenyl)-2-ethyl-9-methyl-4H,6H-1,5-dithia-7,8,9a-triaza-cyclopenta[e]azulene

5-(2-Chloro-phenyl)-7-ethyl-1,5-dihydro-thieno[2,3-e][1,4]thiazepine-2-thione

5-(2-Chloro-phenyl)-7-ethyl-1,5-dihydro-thieno[2,3-e][1,4]thiazepin-2-one

[(2-tert-Butoxycarbonylamino-5-ethyl-thiophen-3-yl)-(2-chloro-phenyl)-methylsulfanyl]-acetic acid