Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

Base Information

Chemical Name:Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester
CAS No.:144066-97-7
Molecular Formula:C₄₀H₆₄O₈Si₂
Molecular Weight:729.114
Hs Code.:

Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

Synonyms:Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

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Chemical Property of Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

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Technology Process of Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

There total 9 articles about Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 144066-96-6
Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-hydroxy-4-hydroxymethyl-4-methyl-cyclohexyl ester

: 144066-97-7
Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1039/c39920001118

Reference yield:

: 496-64-0
3-hydroxy-2-pyrone

: 144066-97-7
Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) PhB(OH)2, 2.) 2,2-dimethylpropane-1,3-diol / 1.) benzene, 90 deg C, 48 h, 2.) benzene, 25 deg C, 30 min

2: 80 percent / KH, n-Bu₄NI / tetrahydrofuran / 1.5 h / 0 - 25 °C

3: 90 percent / Red-Al / hexane; tetrahydrofuran / 1 h / Heating

4: 100 percent / camphorsulfonic acid (CSA) / CH₂Cl₂

5: 1.) BH₃*THF, 2.) H₂O₂, NaOH / 1.) CH₂Cl₂, 25 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 30 min

6: 90 percent / DMAP / CH₂Cl₂ / 0.33 h / 25 °C

7: 100 percent / camphorsulfonic acid (CSA) / methanol

8: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 25 °C

With 2,6-dimethylpyridine; dmap; sodium hydroxide; borane-THF; camphor-10-sulfonic acid; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; potassium hydride; 2,2-Dimethyl-1,3-propanediol; sodium bis(2-methoxyethoxy)aluminium dihydride; phenylboronic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/c39920001118

Reference yield:

: 100-39-0
benzyl bromide

: 144066-97-7
Acetic acid (1S,2R,3S,4S,5R)-2-acetoxymethyl-2-benzyloxy-3-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / KH, n-Bu₄NI / tetrahydrofuran / 1.5 h / 0 - 25 °C

2: 90 percent / Red-Al / hexane; tetrahydrofuran / 1 h / Heating

3: 100 percent / camphorsulfonic acid (CSA) / CH₂Cl₂

4: 1.) BH₃*THF, 2.) H₂O₂, NaOH / 1.) CH₂Cl₂, 25 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 30 min

5: 90 percent / DMAP / CH₂Cl₂ / 0.33 h / 25 °C

6: 100 percent / camphorsulfonic acid (CSA) / methanol

7: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 25 °C

With 2,6-dimethylpyridine; dmap; sodium hydroxide; borane-THF; camphor-10-sulfonic acid; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/c39920001118