4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

Base Information

• Chemical Name: 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
• CAS No.: 1421373-00-3
• Molecular Formula: C₁₈H₁₉BrN₆O
• Molecular Weight: 415.292

Synonyms:4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

Chemical Property of 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

Chemical Property:

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Technology Process of 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

There total 5 articles about 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine (1421373-01-4) → 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine (1421373-00-3)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 1.5h; Reflux;

Reference yield:

4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2) → 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine (1421373-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 16 h / Inert atmosphere; Reflux

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; In ethanol; water;

Reference yield:

3-(2-chloropyrimidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine (1421372-93-1) → 4-bromo-6-methoxy-N-[4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine (1421373-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 16 h / Inert atmosphere; Reflux

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; In ethanol; water;

upstream raw materials:

4-bromo-2-methoxy-5-nitrobenzenamine

3-(2-chloropyrimidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine

N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-amine

4-bromo-2-methoxyaniline

Downstream raw materials:

C₂₇H₃₁N₇O₂

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

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