4-bromo-2-methoxy-5-nitrobenzenamine

Base Information

• Chemical Name: 4-bromo-2-methoxy-5-nitrobenzenamine
• CAS No.: 1421371-97-2
• Molecular Formula: C₇H₇BrN₂O₃
• Molecular Weight: 247.048
• Mol file: 1421371-97-2.mol

Synonyms:4-bromo-2-methoxy-5-nitrobenzenamine

Chemical Property of 4-bromo-2-methoxy-5-nitrobenzenamine

Chemical Property:

Purity/Quality:

99.00% ^*data from raw suppliers

4-Bromo-2-Methoxy-5-Nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-methoxy-5-nitrobenzenamine

There total 4 articles about 4-bromo-2-methoxy-5-nitrobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

4-bromo-2-methoxyaniline (59557-91-4) → 4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at -15 - 20 ℃; for 2h;

DOI:10.1016/j.bioorg.2021.105471

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → 4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 8 h / 25 °C / Inert atmosphere; Reflux

2: iron; ammonium chloride; water / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

3: potassium nitrate; sulfuric acid / 0.08 h / -20 °C / Inert atmosphere

With sulfuric acid; water; iron; ammonium chloride; potassium nitrate; In tetrahydrofuran; methanol;

Reference yield:

4-bromo-2-methoxy-1-nitro-benzene (103966-66-1) → 4-bromo-2-methoxy-5-nitrobenzenamine (1421371-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride; water / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

2: potassium nitrate; sulfuric acid / 0.08 h / -20 °C / Inert atmosphere

With sulfuric acid; water; iron; ammonium chloride; potassium nitrate; In tetrahydrofuran;

upstream raw materials:

4-bromo-2-methoxyaniline

4-bromo-2-methoxy-1-nitro-benzene

4-bromo-2-fluoronitrobenzene

2-methoxy-phenylamine

Downstream raw materials:

C₂₉H₃₀N₆O₂

C₂₇H₂₇N₇O₂

6-methoxy-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{5-methyl-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]-5-methyl-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-amine

Refernces

• 1、 -. "EGFR tyrosine kinase of selective inhibitors of clinically significant mutant". Paragraph 0435; 0442-0445. . Retrieved 2019/03/28.
• 2、 -. "Amino pyrimidine compound and preparation method and application thereof". Paragraph 0789; 0792; 0793; 0794. . Retrieved 2018/11/22.