2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde

Base Information

• Chemical Name: 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde
• CAS No.: 161124-93-2
• Molecular Formula: C₁₇H₁₃Cl₂NO₂
• Molecular Weight: 334.202
• Mol file: 161124-93-2.mol

Synonyms:2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde

Chemical Property of 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde

There total 1 articles about 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-methoxy-1H-indole-3-carboxaldehyde (23872-25-5) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde (161124-93-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 10 min, 2.) DMF, 90 deg C, 1 h;

DOI:10.1016/0223-5234(94)90115-5

Reference yield:

2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde (161124-93-2) → 2-chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indole-3-carboxylic acid (777858-01-2)

Guidance literature:

With potassium permanganate; In water; acetone; at 20 ℃;

DOI:10.1016/j.ejmech.2004.06.008

Reference yield:

2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde (161124-93-2) → 2-chloro-1-(4-chloro-benzyl)-5-hydroxy-1H-indole-3-carboxylic acid (777858-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KMnO₄ / acetone; H₂O / 20 °C

2.1: BBr₃ / CH₂Cl₂ / 20 °C

2.2: aq. NaOH / CH₂Cl₂ / 0.17 h / 20 °C

With potassium permanganate; boron tribromide; In dichloromethane; water; acetone;

DOI:10.1016/j.ejmech.2004.06.008

upstream raw materials:

2-chloro-5-methoxy-1H-indole-3-carboxaldehyde

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

(E)-3-[2-Chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indol-3-yl]-acrylic acid ethyl ester

(E)-3-[2-Chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indol-3-yl]-2-methyl-acrylic acid ethyl ester

2-chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indole-3-carboxylic acid

2-chloro-1-(4-chloro-benzyl)-5-hydroxy-1H-indole-3-carboxylic acid