23872-25-5

Upstream product

• 7699-18-5 5-methoxyindolin-2-one 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1027383-86-3 (E)-3-[2-Chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indol-3-yl]-2-methyl-acrylic acid ethyl ester 
• 1026717-48-5 (E)-3-[2-Chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indol-3-yl]-acrylic acid ethyl ester 
• 777858-05-6 2-chloro-1-(4-chloro-benzyl)-5-hydroxy-1H-indole-3-carboxylic acid 
• 777858-03-4 2-chloro-5-methoxy-1-(4-methoxy-benzyl)-1H-indole-3-carboxylic acid 
• 777858-01-2 2-chloro-1-(4-chloro-benzyl)-5-methoxy-1H-indole-3-carboxylic acid 
• 777857-99-5 2-chloro-5-methoxy-1-(4-methoxy-benzyl)-1H-indole-3-carbaldehyde 
• 161124-93-2 2-chloro-1-(4-chlorobenzyl)-5-methoxyindole-3-carboxaldehyde 

Relevant academic research and scientific papers

A cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes to access thieno[2,3-b]indoles and benzothiophenes

The first catalyst-free cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes was developed. A series of thieno[2,3-b]indoles and benzothiophenes were smoothly obtained in high to excellent yields. The salient features of the protocol include catalyst-free conditions, an environment-friendly solvent, broad substrate scope, and large-scale synthesis.

BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A benzofuran-based N-acylhydrazone derivative according to the present invention has an excellent anticancer effect while having low toxicity and excellent solubility, and, thus, a pharmaceutical composition comprising the derivative can be usefully used to prevent or treat a cell proliferative disorder including various cancers. To this end, the present invention provides a compound represented by chemical formula 1, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.

Organocatalytic enantioselective tandem sulfa-Michael/aldol reaction to access dihydrothiopyran-fused benzosulfolane skeletons bearing three contiguous stereocenters

The first organocatalytic diastereo- and enantioselective tandem sulfa-Michael/aldol reaction of 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes with benzo[b]thiophene sulfones was developed. With multiple hydrogen-bonding thiourea as a catalyst, a wide range of polycyclic dihydrothiopyran-fused benzosulfolanes were smoothly obtained with excellent results (up to 99% yield, 420 : 1 dr and 99% ee) under mild reaction conditions.