7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

Chemical Name:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497850-34-7
Molecular Formula:C₃₉H₄₉N₅O₃S
Molecular Weight:667.916
Hs Code.:

Synonyms:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Property of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Technology Process of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 6 articles about 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 313736-34-4
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 497850-34-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride; With sodium hydroxide; more than 3 stages;

Reference yield:

: 3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497850-34-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; 7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 497855-00-2
(4-propyl-4H-1,2,4-triazol-3-yl)methanol

: 497850-34-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 34 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.10.021