7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide

Base Information

• Chemical Name: 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide
• CAS No.: 497850-35-8
• Molecular Formula: C₃₉H₄₉N₅O₄S
• Molecular Weight: 683.915
• Mol file: 497850-35-8.mol

Synonyms:

Chemical Property of 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide

There total 8 articles about 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide (497850-34-7) → 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide (497850-35-8,497850-75-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; cooling;

DOI:10.1016/j.bmc.2004.10.021

Reference yield:

(4-propyl-4H-1,2,4-triazol-3-yl)methanol (497855-00-2) → 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide (497850-35-8,497850-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 34 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

3.1: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / cooling

With thionyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2004.10.021

Reference yield:

(4-propyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)methanol (497854-99-6) → 7-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-[4-(4-propyl-4H-1,2,4-triazol-3-ylmethylsulfinyl)phenyl]-2,3-dihydro-1H-benzazepine-4-carboxamide (497850-35-8,497850-75-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 73 percent / NaNO₂; HNO₃

2.1: 34 percent / SOCl₂ / Heating

3.1: Et₃N / tetrahydrofuran / 0 - 20 °C

3.2: NaOH / methanol; tetrahydrofuran / 20 °C

3.3: methanol; tetrahydrofuran / 20 °C

4.1: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / cooling

With thionyl chloride; nitric acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2004.10.021

upstream raw materials:

7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

(4-propyl-4H-1,2,4-triazol-3-yl)methanol

(4-propyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)methanol

S-<(benzyloxy)carbonyl>-4-aminobenzenethiol