(3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene

Base Information

• Chemical Name: (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene
• CAS No.: 1190883-16-9
• Molecular Formula: C₂₉H₅₁F₃O₂SiSn
• Molecular Weight: 635.513
• Mol file: 1190883-16-9.mol

Synonyms:(3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene

Chemical Property of (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene

There total 1 articles about (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C23H37F3O2Sn (1190883-15-8) + tert-butyldimethylsilyl chloride (18162-48-6) → (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene (1190883-16-9)

Guidance literature:

With 1H-imidazole; In toluene; at 0 - 10 ℃; Inert atmosphere;

Reference yield:

(Z)-7-[(3R)-3-(tert-butyldimethylsilanyloxy)-5-oxo-cyclopent-1-enyl]hept-5-enoic acid isopropyl ester (474944-36-0) + (3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene (1190883-16-9) → (Z)-7-((1R,2R,3R)-3-[(tert-butyldimethylsilanyl)oxy]2-((E)-3-((tert-butyldimethylsilanyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-oxo-cyclopentyl)hept-5-enoic acid isopropyl ester (1190883-19-2)

Guidance literature:

(3R,E)-3-(tert-butyldimethylsilyloxy)-1-(tributylstannyl)-4-(3-(trifluoromethyl)-phenoxy)-but-1-ene; With methyllithium; copper(l) cyanide; In tetrahydrofuran; diethyl ether;

(Z)-7-[(3R)-3-(tert-butyldimethylsilanyloxy)-5-oxo-cyclopent-1-enyl]hept-5-enoic acid isopropyl ester; In tetrahydrofuran; diethyl ether; at -80 - -70 ℃;

upstream raw materials:

C₂₃H₃₇F₃O₂Sn

tert-butyldimethylsilyl chloride

Downstream raw materials:

(Z)-7-((1R,2R,3R)-3-[(tert-butyldimethylsilanyl)oxy]2-((E)-3-((tert-butyldimethylsilanyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-5-oxo-cyclopentyl)hept-5-enoic acid isopropyl ester