(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

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Chemical Name:(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid
CAS No.:1259278-91-5
Molecular Formula:C₁₈H₁₇ClFN₅O₂
Molecular Weight:389.817
Hs Code.:

Synonyms:(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

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Chemical Property of (1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

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Technology Process of (1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

There total 6 articles about (1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₃ClFN₅O₄S

: 1259278-91-5
(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

Guidance literature:: With lithium hydroxide; at 120 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jm5007275

Reference yield:

: IPr₂NEt

: 1259009-31-8
5-chloro-3-(5-fluoro-4-methylsulfonyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

: 5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2
rac-trans-2-aminocyclohexanecarboxylic acid

: 1259278-91-5
(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

Guidance literature:: With LiOH; sodium carbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1259009-31-8
5-chloro-3-(5-fluoro-4-methylsulfonyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

: 1259278-91-5
(1S,2S)-2-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h

3: sodium carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 0.5 h / 130 °C / Sealed tube; Microwave irradiation

4: lithium hydroxide / 0.17 h / 120 °C / Microwave irradiation

With sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm5007275