(1R,2R)-2-azaniumylcyclohexane-1-carboxylate

Base Information

• Chemical Name: (1R,2R)-2-azaniumylcyclohexane-1-carboxylate
• CAS No.: 5691-19-0
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• Hs Code.: 2922499990
• Mol file: 5691-19-0.mol

Synonyms:

Chemical Property of (1R,2R)-2-azaniumylcyclohexane-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.00103mmHg at 25°C
• Melting Point: ~255 °C (dec.)
• Refractive Index: 1.4150 (estimate)
• Boiling Point: 280°Cat760mmHg
• PKA: 3.77±0.28(Predicted)
• Flash Point: 123.1°C
• PSA: 63.32000
• Density: 1.133g/cm³
• LogP: 1.28880
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-2-Aminocyclohexanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)C(=O)[O-])[NH3+]
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)C(=O)[O-])[NH3+]

Technology Process of (1R,2R)-2-azaniumylcyclohexane-1-carboxylate

There total 59 articles about (1R,2R)-2-azaniumylcyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-2-(dibenzylamino)cyclohexane-1-carboxylic acid → (1R,2R)-2-aminocyclohexanecarboxylic Acid (5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 60h; under 1034.32 Torr;

DOI:10.1016/j.tetlet.2014.12.101

Reference yield: 92.0%

(1S,2S)-1-cyano-2-[N-(4-nitrobenzoyl)amino]cyclohexane (864445-67-0) → rac-trans-2-aminocyclohexanecarboxylic acid (5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2)

Guidance literature:

With hydrogenchloride; at 90 ℃; for 120h;

DOI:10.1021/ja053486y DOI:10.1016/j.tet.2007.02.081

Reference yield: 89.0%

(3S,4S)-3-(N'-p-methoxycarbonylbenzyloxycarbonylamino)-1-cyclohexene-4-carboxylic acid (506444-80-0) → rac-trans-2-aminocyclohexanecarboxylic acid (5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 22h; under 760.051 Torr;

DOI:10.1021/ja020879d

upstream raw materials:

cyclohexene-1-carboxylic acid

anthranilic acid

(-)-(R,R)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid

(1S,2S)-2-aminocyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

(+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid

(-)-(1R,2R)-2-(2,4-Dinitroanilino)cyclohexanecarboxylic acid

(1R,2R)-2-Amino-cyclohexanecarboxylic acid (4-chloro-phenyl)-amide

trans-N-phenyl-2-aminocyclohexanecarboxamide

Refernces

Synthesis of enantiopure cis- and trans-2-aminocyclohexane-1-carboxylic acids from octahydroquinazolin-4-ones

10.1016/j.tetasy.2004.08.032

The research describes a method for the synthesis of enantiomerically pure cis- and trans-2-aminocyclohexane-1-carboxylic acids, which are significant due to their potential therapeutic applications and role in forming stable secondary structures in β-peptides. The study utilizes 2-aminobenzamide as a chiral block to assemble quinazolinone, aiming to provide a new synthesis route for all four isomers of 2-aminocyclohexanecarboxylic acid. The process involves chemoselective and diastereoselective hydrogenation of 2,3-dihydro-3-[(S)-α-methylbenzyl]-4-quinazolinone to produce octahydroquinazolinones, which can be epimerized to form their respective stereoisomers. Hydrolysis of these octahydroquinazolinones with HCl yields the desired enantiomerically pure amino acids.