4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

Base Information

Chemical Name:4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide
CAS No.:103892-56-4
Molecular Formula:C₂₄H₃₈N₄O₂
Molecular Weight:414.591
Hs Code.:

Synonyms:4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

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Chemical Property of 4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

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Technology Process of 4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

There total 7 articles about 4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

: 138848-87-0
[(S)-5-{[4-(Benzyloxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-5-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-carbamic acid benzyl ester

: 103892-56-4
4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

Guidance literature:: With hydrogen; palladium; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2340

Reference yield:

: 27687-13-4
trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride

: 103892-56-4
4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

2: 59.2 percent / H₂ / Pd / dimethylformamide

With hydrogen; triethylamine; palladium; In chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2340

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 103892-56-4
4-Aminomethyl-cyclohexanecarboxylic acid [(S)-5-amino-1-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1) ethyl chloroformate / 2) THF, r.t., overnight

2: 5.5 N HCl / dioxane

3: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

4: 59.2 percent / H₂ / Pd / dimethylformamide

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2340