2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine

Base Information

• Chemical Name: 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine
• CAS No.: 871793-25-8
• Molecular Formula: C₁₅H₁₅F₃N₂OS
• Molecular Weight: 328.358
• Mol file: 871793-25-8.mol

Synonyms:2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine

Chemical Property of 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine

There total 2 articles about 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dioxo-6-hydroxy-1-(3-trifluoromethylphenyl)-hexane (871793-24-7) + S-methylthiouronium iodide (4338-95-8) → 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine (871793-25-8)

Guidance literature:

1,3-dioxo-6-hydroxy-1-(3-trifluoromethylphenyl)-hexane; S-methylthiouronium iodide; In isopropyl alcohol; at 100 ℃; for 4h;

With triethylamine; In methanol; at 20 ℃; Reflux;

DOI:10.1016/j.bmcl.2010.08.101

Reference yield:

3'-(trifluoromethyl)acetophenone (349-76-8) → 2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine (871793-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol; sodium hydride / diethyl ether / 72.5 h / 0 - 20 °C

2.1: isopropyl alcohol / 4 h / 110 °C

2.2: 6 h / 20 - 85 °C / Heating / reflux

With ethanol; sodium hydride; In diethyl ether; isopropyl alcohol;

Reference yield:

2-methylsulfanyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)pyrimidine (871793-25-8) → 2-methanesulphonyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)-pyrimidine

Guidance literature:

With oxone(R); In water; acetonitrile; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2010.08.101

upstream raw materials:

1,3-dioxo-6-hydroxy-1-(3-trifluoromethylphenyl)-hexane

S-methylthiouronium iodide

3'-(trifluoromethyl)acetophenone

Downstream raw materials:

4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile