4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

Base Information

Chemical Name:4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile
CAS No.:871793-23-6
Molecular Formula:C₁₅H₁₂F₃N₃O
Molecular Weight:307.275
Hs Code.:

Synonyms:4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

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Chemical Property of 4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

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Technology Process of 4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

There total 4 articles about 4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 2-methanesulphonyl-4-(3-hydroxypropyl)-6-(3-trifluoromethylphenyl)-pyrimidine

: 871793-23-6
4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2010.08.101

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 871793-23-6
4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium hydride / diethyl ether / 72.5 h / 0 - 20 °C

2.1: isopropyl alcohol / 4 h / 110 °C

2.2: 6 h / 20 - 85 °C / Heating / reflux

3.1: potassium peroxymonosulfate / methanol; water / 3 h / 20 °C

4.1: dimethyl sulfoxide / 0.75 h / 20 °C

With potassium peroxymonosulfate; ethanol; sodium hydride; In methanol; diethyl ether; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 871793-24-7
1,3-dioxo-6-hydroxy-1-(3-trifluoromethylphenyl)-hexane

: 871793-23-6
4-(3-hydroxy-1-propyl)-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 4 h / 110 °C

1.2: 6 h / 20 - 85 °C / Heating / reflux

2.1: potassium peroxymonosulfate / methanol; water / 3 h / 20 °C

3.1: dimethyl sulfoxide / 0.75 h / 20 °C

With potassium peroxymonosulfate; In methanol; water; dimethyl sulfoxide; isopropyl alcohol;