4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

Base Information

Chemical Name:4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone
CAS No.:124294-92-4
Molecular Formula:C₁₅H₁₆N₄O₂
Molecular Weight:284.318
Hs Code.:

Synonyms:4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

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Chemical Property of 4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

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Technology Process of 4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

There total 4 articles about 4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 124294-91-3
4,5-Dihydro-6-(3-amino-4-cyanophenyl)-5-methyl-3(2H)-pyridazinone

: 122-51-0
orthoformic acid triethyl ester

: 124294-92-4
4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

Guidance literature:: With trifluoroacetic acid; at 80 ℃; for 1h;
DOI:10.1248/cpb.39.352

Reference yield:

: 124294-88-8
(+/-)-4-(4-bromo-3-nitrophenyl)-3-methyl-4-oxobutyric acid

: 124294-92-4
4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / hydrazine hydrate / acetic acid / 3 h / 100 °C

2: 58 percent / dimethylformamide / 2.5 h / 100 °C

3: 67 percent / SnCl₂*2H₂O; conc. HCl / dimethylformamide / 0.5 h / 5 - 10 °C

4: 82 percent / CF₃COOH / 1 h / 80 °C

With hydrogenchloride; hydrazine hydrate; trifluoroacetic acid; tin(ll) chloride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.352

Reference yield:

: 124294-89-9
6-(4-bromo-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one

: 124294-92-4
4,5-Dihydro-6-<4-cyano-3-(ethoxymethyleneamino)phenyl>-5-methyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / dimethylformamide / 2.5 h / 100 °C

2: 67 percent / SnCl₂*2H₂O; conc. HCl / dimethylformamide / 0.5 h / 5 - 10 °C

3: 82 percent / CF₃COOH / 1 h / 80 °C

With hydrogenchloride; trifluoroacetic acid; tin(ll) chloride; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.352