5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde

Base Information

• Chemical Name: 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde
• CAS No.: 1259391-09-7
• Molecular Formula: C₃₀H₃₁NO₅
• Molecular Weight: 485.58
• Mol file: 1259391-09-7.mol

Synonyms:5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde

Chemical Property of 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde

There total 8 articles about 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C30H33NO5 (1259391-16-6) → 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde (1259391-09-7)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm101233f

Reference yield:

benzyl 5-bromomethyl-2-propoxybenzoate (1259391-06-4) → 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde (1259391-09-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

1.2: -50 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

3.1: borane-THF / tetrahydrofuran / 20 °C

4.1: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; 1.1: Evan's asymmetric alkylation / 1.2: Evan's asymmetric alkylation;

DOI:10.1021/jm101233f

Reference yield:

benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate (1259391-07-5) → 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde (1259391-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 735.07 Torr

2: borane-THF / tetrahydrofuran / 20 °C

3: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; borane-THF; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1021/jm101233f

upstream raw materials:

benzyl 5-bromomethyl-2-propoxybenzoate

benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

C₃₀H₃₃NO₅

Downstream raw materials:

(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-3-cyclohexylpropanoic acid

N-((5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxyphenyl)methyl)-4-(1-adamantanyl)benzamide

C₃₄H₃₅NO₄

C₄₄H₄₄N₂O₅