benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

Base Information

Chemical Name:benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate
CAS No.:1259391-07-5
Molecular Formula:C₃₇H₃₇NO₆
Molecular Weight:591.704
Hs Code.:

Synonyms:benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

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Chemical Property of benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

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Technology Process of benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

There total 6 articles about benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1259391-06-4
benzyl 5-bromomethyl-2-propoxybenzoate

: 136159-65-4,96930-27-7
(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one

: 1259391-07-5
benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

Guidance literature:: (S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -50 - -15 ℃; Inert atmosphere;

benzyl 5-bromomethyl-2-propoxybenzoate; In tetrahydrofuran; at -50 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm101233f

Reference yield:

: 100-39-0
benzyl bromide

: 1259391-07-5
benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

3.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

4.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

5.2: -50 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; potassium hydrogencarbonate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 5.1: Evan's asymmetric alkylation / 5.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f

Reference yield:

: 176047-66-8
benzyl 2-hydroxy-5-formylbenzoate

: 1259391-07-5
benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

2.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

3.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

4.2: -50 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 4.1: Evan's asymmetric alkylation / 4.2: Evan's asymmetric alkylation;
DOI:10.1021/jm101233f