ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

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Chemical Name:ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate
CAS No.:345296-38-0
Molecular Formula:C₂₁H₂₄N₄O₄
Molecular Weight:396.446
Hs Code.:

Synonyms:ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

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Chemical Property of ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

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Technology Process of ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

There total 4 articles about ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 345297-66-7
ethyl 3-{(1-(3-nitrophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)propanoate

: 345296-38-0
ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

Guidance literature:: With acetic acid; zinc; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.03.033

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 345296-38-0
ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / 8 h / 110 °C

2: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 8 h / 20 °C

3: 80 percent / Zn; aq. AcOH / tetrahydrofuran

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.033

Reference yield:

: 345297-65-6
1-(3-nitro-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid

: 345296-38-0
ethyl 3-{(1-(3-aminophenyl)-5-oxopyrrolidin-3-yl)carbonylamino}-3-(pyridin-3-yl)-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 8 h / 20 °C

2: 80 percent / Zn; aq. AcOH / tetrahydrofuran

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.033