(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

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Chemical Name:(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid
CAS No.:1202576-56-4
Molecular Formula:C₂₁H₂₀F₄O₄
Molecular Weight:412.381
Hs Code.:

Synonyms:(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

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Chemical Property of (3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

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Technology Process of (3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

There total 12 articles about (3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1202577-97-6
(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

: 1202576-56-4
(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

Guidance literature:: (3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol; With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In water; acetonitrile; at 0 - 10 ℃; Phosphate buffer;

With water; sodium hydroxide; In acetonitrile; at 0 ℃; pH=8 - 9;

With hydrogenchloride; In water; acetonitrile; pH=3 - 4;

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 1202576-56-4
(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; formic acid / 0 - 35 °C / Inert atmosphere

1.2: 2 h / 35 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

8.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile; water / 0 - 10 °C / Phosphate buffer

8.2: 0 °C / pH 8 - 9

8.3: pH 3 - 4

With 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; lithium aluminium tetrahydride; formic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1202577-76-1
(1S)-1-(4-benzyloxyphenyl)-3-(triisopropylsilyloxy)propan-1-ol

: 1202576-56-4
(3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile; water / 0 - 10 °C / Phosphate buffer

5.2: 0 °C / pH 8 - 9

5.3: pH 3 - 4

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;