(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Base Information

Chemical Name:(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol
CAS No.:1202577-97-6
Molecular Formula:C₂₁H₂₂F₄O₃
Molecular Weight:398.397
Hs Code.:

Synonyms:(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

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Chemical Property of (3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

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Technology Process of (3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

There total 11 articles about (3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1202577-96-5
{[(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propyl]oxy}(triisopropyl)silane

: 1202577-97-6
(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 1202577-97-6
(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; formic acid / 0 - 35 °C / Inert atmosphere

1.2: 2 h / 35 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; formic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202577-75-0
(1S)-1-(4-benzyloxyphenyl)propan-1,3-diol

: 1202577-97-6
(3S)-3-Ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;