3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

Base Information

Chemical Name:3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran
CAS No.:333385-07-2
Molecular Formula:C₂₁H₂₇BrO₂
Molecular Weight:391.348
Hs Code.:

Synonyms:3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

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Chemical Property of 3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

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Technology Process of 3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

There total 8 articles about 3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 333385-23-2
2-(3-bromo-5-methoxy-benzofuran-2-yl)-4-(6,6-dimethyl-cyclohex-1-enyl)-butan-2-ol

: 333385-07-2
3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

Guidance literature:: With sodium cyanoborohydride; zinc(II) iodide; In 1,2-dichloro-ethane; for 2.5h; Heating;
DOI:10.1021/ja0021060

Reference yield:

: 333385-05-0
3-bromo-5-methoxybenzofuran-2-carboxylic acid

: 333385-07-2
3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-toluenesulfonyl chloride / pyridine / 0.33 h / 0 °C

1.2: 78 percent / pyridine / 1 h / 0 °C

2.1: pyridine / toluene; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: 2.66 g / toluene / 1 h / Heating

4.1: 78 percent / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

5.1: 86 percent / zinc iodide; sodium cyanoborohydride / 1,2-dichloro-ethane / 2.5 h / Heating

With pyridine; sodium cyanoborohydride; p-toluenesulfonyl chloride; zinc(II) iodide; In tetrahydrofuran; pyridine; diethyl ether; 1,2-dichloro-ethane; toluene; 3.1: Claisen rearrangement;
DOI:10.1021/ja0021060

Reference yield:

: 263862-77-7
1-(3-bromo-5-methoxy-benzofuran-2-yl)-3-(6,6-dimethyl-cyclohex-1-enyl)-propan-1-one

: 333385-07-2
3-bromo-2-[3-(6,6-dimethyl-cyclohex-1-enyl)-1-methyl-propyl]-5-methoxy-benzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2: 86 percent / zinc iodide; sodium cyanoborohydride / 1,2-dichloro-ethane / 2.5 h / Heating

With sodium cyanoborohydride; zinc(II) iodide; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane;
DOI:10.1021/ja0021060