(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

Base Information

Chemical Name:(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione
CAS No.:1400677-89-5
Molecular Formula:C₃₄H₃₄N₂O₆
Molecular Weight:566.654
Hs Code.:

Synonyms:(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

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Chemical Property of (2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

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Technology Process of (2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

There total 3 articles about (2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1400676-01-8
(S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione

: 74-88-4
methyl iodide

: 1400677-89-5
(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

Guidance literature:: (S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1400675-96-8
(E)-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione

: 1400677-89-5
(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 2 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 20 °C

With sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 29311-53-3
(E)-3-hexene-1,6-dioic acid

: 1400677-89-5
(2S,5S,E)-2-benzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methylhex-3-ene-1,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pivaloyl chloride; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 2.75 h / -78 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: 2 h / 0 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 20 °C

With 4-methyl-morpholine; sodium hexamethyldisilazane; pivaloyl chloride; In tetrahydrofuran;