2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

Base Information

Chemical Name:2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt
CAS No.:1273307-62-2
Molecular Formula:C₂₀H₂₀F₃N₅O₃*ClH
Molecular Weight:471.867
Hs Code.:

Synonyms:2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

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Chemical Property of 2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

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Technology Process of 2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

There total 8 articles about 2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1273316-14-5
2-(2-methoxyethyl)-9-methyl-7,9-dihydro-8H-purine-8-one

: 1273316-06-5
3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

: 1273307-62-2
2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

Guidance literature:: bis(trichloromethyl) carbonate; 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

2-(2-methoxyethyl)-9-methyl-7,9-dihydro-8H-purine-8-one; With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 17587-95-0
2-chloro-N⁴-methylpyrimidine-4,5-diamine

: 1273307-62-2
2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 12 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide

3.1: triethylamine; XPhos / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 0.5 h / 120 °C / Inert atmosphere

4.1: cesiumhydroxide monohydrate / methanol / 1 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

7.2: 3 h / 20 °C

With cesiumhydroxide monohydrate; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1273315-11-9
2-chloro-9-methyl-7H-purin-8(9H)-one

: 1273307-62-2
2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide

2.1: triethylamine; XPhos / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 0.5 h / 120 °C / Inert atmosphere

3.1: cesiumhydroxide monohydrate / methanol / 1 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

6.2: 3 h / 20 °C

With cesiumhydroxide monohydrate; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;