3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

Base Information

• Chemical Name: 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt
• CAS No.: 1273316-06-5
• Molecular Formula: C₂HF₃O₂*C₁₀H₁₀F₃N
• Molecular Weight: 315.215
• Mol file: 1273316-06-5.mol

Synonyms:3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

Chemical Property of 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

Chemical Property:

Purity/Quality:

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Technology Process of 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

There total 2 articles about 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt (1273316-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel(II) iodide; trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane / isopropyl alcohol; tetrahydrofuran / 0.5 h / 20 - 80 °C / Inert atmosphere; Microwave irradiation

2: dichloromethane / 12 h / 0 - 20 °C

With nickel(II) iodide; trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1021/jacs.0c05131

Reference yield:

tert-butyl 3-(4-(trifluoromethyl)phenyl)azetidine-1-carboxylate + trifluoroacetic acid (76-05-1) → 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt (1273316-06-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/jacs.0c05131

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 2-(3-methoxypropyl)-9-methyl-7,9-dihydro-8H-purine-8-one (1273316-04-3) + 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt (1273316-06-5) → 2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one (1273388-39-8)

Guidance literature:

bis(trichloromethyl) carbonate; 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

2-(3-methoxypropyl)-9-methyl-7,9-dihydro-8H-purine-8-one; With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; at 20 ℃; for 0.166667h;

upstream raw materials:

4-trifluoromethylphenylboronic acid

trifluoroacetic acid

Downstream raw materials:

2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt

1-benzhydryl-3-(4-(trifluoromethyl)phenyl)azetidine