(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

Base Information

Chemical Name:(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide
CAS No.:347383-70-4
Molecular Formula:C₂₄H₂₆F₃N₃O₅
Molecular Weight:493.483
Hs Code.:

Synonyms:(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

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Chemical Property of (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

Chemical Property:

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Technology Process of (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

There total 1 articles about (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 243121-08-6
(S)-4-benzyl-3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-one

: 2-amino-N-benzyloxy-propionamide; compound with trifluoro-acetic acid

: 347383-70-4
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

: 347383-69-1
(S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1016/S0040-4039(01)00375-6

Reference yield: 75.0%

: 347383-70-4
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

: 347383-75-9
(S)-3-((S)-1-Benzyloxycarbamoyl-ethylamino)-4,4,4-trifluoro-butyric acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(01)00375-6

Reference yield:

: 347383-70-4
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide

: (S)-3-Methyl-2-[(S)-4,4,4-trifluoro-3-((S)-1-hydroxycarbamoyl-ethylamino)-butyrylamino]-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / lithium hydroxide; H₂O₂ / 0.5 h / 0 °C

2: HATU; 1-hydroxy-7-azabenzotriazole; sym-collidine / dimethylformamide

3: hydrogen / Pd(OH)2/C

With 2,4,6-trimethyl-pyridine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; dihydrogen peroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium dihydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)00375-6