(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

Base Information

Chemical Name:(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one
CAS No.:897961-42-1
Molecular Formula:C₃₇H₆₆O₄S₂Si₃
Molecular Weight:723.317
Hs Code.:

Synonyms:(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

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Chemical Property of (2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

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Technology Process of (2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

There total 11 articles about (2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-80-8
1.3-propanedithiol

: 897961-41-0
(2S)-1-benzyloxy-2,9-bistriethylsilanyloxy-12-trimethylsilanyldodeca-4,11-diyn-6-one

: 897961-42-1
(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

Guidance literature:: With sodium methylate; In methanol; dichloromethane; at 20 ℃; for 18h;
DOI:10.1039/b603015g

Reference yield:

: 897961-35-2
(9S)-10-benzyloxy-9-triethylsilanyloxydec-1-en-6-yn-5-one

: 897961-42-1
(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 13 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: BF₃*THF / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.3: 50 percent / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

3.1: 98 percent / imidazole / tetrahydrofuran / 2 h / 20 °C

4.1: 90 percent / NaOMe / methanol; CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; disodium hydrogenphosphate; n-butyllithium; sodium methylate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/b603015g

Reference yield:

: 897961-94-3
(1S)-(1-benzyloxymethyl-but-3-ynyloxy)-triethyl-silane

: 897961-42-1
(2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 87 percent / tetrahydrofuran / 18 h / -78 - 20 °C

2.1: 96 percent / tetrahydrofuran / 4 h / 30 °C

3.1: 97 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

4.1: 75 percent / mCPBA; Na₂HPO₄ / CH₂Cl₂ / 13 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: BF₃*THF / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.3: 50 percent / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

6.1: 98 percent / imidazole / tetrahydrofuran / 2 h / 20 °C

7.1: 90 percent / NaOMe / methanol; CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; disodium hydrogenphosphate; n-butyllithium; sodium methylate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; 3.1: Dess-Martin oxidation;
DOI:10.1039/b603015g