4-(2-Amino-1-hydroxyethyl)phenol;hydron;chloride

Base Information

• Chemical Name: 4-(2-Amino-1-hydroxyethyl)phenol;hydron;chloride
• CAS No.: 770-05-8
• Molecular Formula: C8H12ClNO2
• Molecular Weight: 189.642
• Hs Code.: 2922199090
• Mol file: 770-05-8.mol

Synonyms:SCHEMBL9125963

Chemical Property of 4-(2-Amino-1-hydroxyethyl)phenol;hydron;chloride

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 7.82E-06mmHg at 25°C
• Melting Point: 169-171 °C
• Boiling Point: 360.7 °C at 760 mmHg
• Flash Point: 172 °C
• PSA: 66.48000
• Density: 1.39[at 20℃]
• LogP: 1.88660
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: soluble
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 189.0556563
• Heavy Atom Count: 12
• Complexity: 111

Purity/Quality:

98% ^*data from raw suppliers

Octopamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 36-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].C1=CC(=CC=C1C(CN)O)O.[Cl-]
• Uses: Octopamine HCL has the ability to halt catabolism of proteinaceous tissues. It is very important while losing weight to maximize adipose loss while minimizing the loss of muscle and other lean body tissue. Octopamine Hcl (norepinephrine) is best known as an effective ephedrine alternative, claiming to boost energy while reduce weight in bodybuilding industry for weight loss purpose. In addition, many users believe octopamine hcl is a good nootropic compound that makes our brain easy to focus, enhances motivation as a wakefulness promoter. A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.

Technology Process of 4-(2-Amino-1-hydroxyethyl)phenol;hydron;chloride

There total 2 articles about 4-(2-Amino-1-hydroxyethyl)phenol;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H11NO2*C7H8N2O*2ClH → octopamine hydrochloride (770-05-8) + N-methylnicotinamide hydrochloride (29711-57-7)

Guidance literature:

at 28 ℃; Equilibrium constant; Thermodynamic data; association enthalpy: ΔH⁰ (kcal mol^-1) = -2.6 (pH=1); -2.3 (pH=7);

DOI:10.1016/0223-5234(89)90014-7

Reference yield:

octopamine hydrochloride (770-05-8) → (+)p-octopamine hydrochloride (770-05-8,4502-14-1,19462-08-9)

Guidance literature:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + octopamine hydrochloride (770-05-8) → tert-butyl (2-hydroxy-2-(4-hydroxyphenyl)ethyl)carbamate (126395-31-1)

Guidance literature:

With sodium hydrogencarbonate; In methanol; water;

DOI:10.1055/s-0029-1217027

Downstream raw materials:

(-)-2-amino-1-(4-hydroxyphenyl)ethanol (1S)-(+)camphor-10-sulphonate

(+)-2-amino-1-(4-hydroxyphenyl)ethanol (1S)-(+)camphor-10-sulphonate

(+)p-octopamine hydrochloride

N-benzoyloctopamine

Refernces

• 1、 Midgley, John M.,Thonoor, Mohan C.,Drake, Alex F.,Williams, Clyde M.,Koziol, Anna E.,Palenik, Gus J.. "The Resolution and Absolute Configuration by X-Ray Crystallography of the Isomeric Octopamines and Synephrines". . p. 963 - 970. Retrieved 2007/10/02.