N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide
CAS No.:1261082-87-4
Molecular Formula:C₂₇H₂₃N₃O₄S
Molecular Weight:485.563
Hs Code.:

Synonyms:N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

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Chemical Property of N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

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Technology Process of N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

There total 4 articles about N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1261082-93-2
3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

: 98-09-9
benzenesulfonyl chloride

: 1261082-87-4
N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm3002982

Reference yield:

: 757978-19-1
5-bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1261082-87-4
N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: water; potassium hydroxide / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: pyridine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; potassium hydroxide; In 1,4-dioxane; dichloromethane; water; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1021/jm3002982

Reference yield:

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1261082-87-4
N-(3-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: water; potassium hydroxide / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: pyridine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; potassium hydroxide; In 1,4-dioxane; dichloromethane; water; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1021/jm3002982