4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Base Information

Chemical Name:4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide
CAS No.:1436422-08-0
Molecular Formula:C₂₁H₂₂BrF₅N₄O
Molecular Weight:521.328
Hs Code.:

Synonyms:4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

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Chemical Property of 4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Chemical Property:

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Technology Process of 4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

There total 10 articles about 4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1436422-08-0
4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 4 h / 80 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

5: hydrogenchloride / acetonitrile; 1,4-dioxane / 20 °C

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1436426-82-2
tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

: 1436422-08-0
4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 20 ℃;

Reference yield:

: 1436426-35-5
1-(5-bromo-2-nitrophenyl)piperazine

: 1436422-08-0
4-(aminomethyl)-N-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

2: ethanol; tin(ll) chloride / 4 h / 80 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

4: hydrogenchloride / acetonitrile; 1,4-dioxane / 20 °C

With hydrogenchloride; ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;