tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

Base Information

Chemical Name:tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate
CAS No.:1436426-82-2
Molecular Formula:C₂₆H₃₀BrF₅N₄O₃
Molecular Weight:621.445
Hs Code.:

Synonyms:tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

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Chemical Property of tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

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Technology Process of tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

There total 9 articles about tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1436426-82-2
tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3: ethanol; tin(ll) chloride / 4 h / 80 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

With ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1436426-36-6
4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 1436426-38-8
4-((tert-butoxycarbonylamino)methyl)-2,3-difluorobenzoic acid

: 1436426-82-2
tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 1436426-35-5
1-(5-bromo-2-nitrophenyl)piperazine

: 1436426-82-2
tert-butyl 4-(4-bromo-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

2: ethanol; tin(ll) chloride / 4 h / 80 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

With ethanol; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;