ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate

Base Information

• Chemical Name: ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate
• CAS No.: 945042-26-2
• Molecular Formula: C₁₈H₂₆O₅
• Molecular Weight: 322.401
• Mol file: 945042-26-2.mol

Synonyms:ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate

Chemical Property of ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate

There total 1 articles about ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

benzyl bromide (100-39-0) + ethyl 3-((4R,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propanoate (124575-39-9,140836-86-8) → ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate (945042-26-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h;

DOI:10.1016/j.bmc.2007.04.011

Reference yield: 26.0%

ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate (945042-26-2) + p-chlorobenzyl cyanide (140-53-4) → (4R,5S)-5-benzyloxymethyl-4-(4-(4-chlorophenyl)-4-cyano-3-oxobutyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:

p-chlorobenzyl cyanide; With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h;

ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 72h; Further stages.;

DOI:10.1016/j.bmc.2007.04.011

Reference yield: 21.0%

ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate (945042-26-2) + phenylacetonitrile (140-29-4) → (4R,5S)-5-benzyloxymethyl-4-(4-cyano-3-oxo-4-phenylbutyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:

phenylacetonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h;

ethyl 3-((4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-5-yl)propanoate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 72h; Further stages.;

DOI:10.1016/j.bmc.2007.04.011

upstream raw materials:

benzyl bromide

ethyl 3-((4R,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propanoate