2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide
CAS No.:1363178-86-2
Molecular Formula:C₂₇H₂₄N₂O₄S₂
Molecular Weight:504.631
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Chemical Property:

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

There total 9 articles about 2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363179-16-1
2-(4-(ethylsulfonyl)phenyl)propanoic acid

: 17279-56-0
(2-amino-4-phenyl-1,3-thiazol-5-yl)(phenyl)methanone

: 1363178-86-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: ethyl 2-(4-(ethylsulfonyl)phenyl)acetate

: 1363178-86-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 20 °C

1.2: pH 1

2.1: thionyl chloride / 20 - 80 °C / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Sealed vial

3.2: 3 h / 0 °C

3.3: pH 5

4.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

4.2: pH 5

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With thionyl chloride; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;

Reference yield:

: 120-46-7,61346-73-4
1,3-diphenylpropanedione

: 1363178-86-2
2-[4-(ethylsulfonyl)phenyl]-N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine / ethyl acetate / 0 °C

1.2: 0.25 h / 85 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate;