Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine
• CAS No.: 117922-45-9
• Molecular Formula: C₆H₁₅N*C₆₃H₅₇ClN₃O₁₂PS
• Molecular Weight: 1247.84

Synonyms:Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine

There total 8 articles about Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (117922-45-9)

Guidance literature:

Multi-step reaction with 5 steps

1: p-toluenesulfonic acid monohydrate / dioxane / 2 h

2: 1M tributylammonium hydrogen fluoride / 3 h / Ambient temperature

3: pyridine

4: 86 percent

5: pyridine-t-BuNH₂-H₂O / 3 h / Ambient temperature

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; tert-butylamine; In 1,4-dioxane;

DOI:10.1246/cl.1988.857

Reference yield:

tritylsulfenyl chloride (24165-03-5) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (117922-45-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 75 percent / triethylamine / CH₂Cl₂ / 8 h / Ambient temperature

2: p-toluenesulfonic acid monohydrate / dioxane / 2 h

3: 1M tributylammonium hydrogen fluoride / 3 h / Ambient temperature

4: pyridine

5: 86 percent

6: pyridine-t-BuNH₂-H₂O / 3 h / Ambient temperature

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; tert-butylamine; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1246/cl.1988.857

Reference yield:

N3-[(triphenylmethyl)sulfenyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (117901-68-5) → Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with triethyl-amine (117922-45-9)

Guidance literature:

Multi-step reaction with 5 steps

1: p-toluenesulfonic acid monohydrate / dioxane / 2 h

2: 1M tributylammonium hydrogen fluoride / 3 h / Ambient temperature

3: pyridine

4: 86 percent

5: pyridine-t-BuNH₂-H₂O / 3 h / Ambient temperature

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; tert-butylamine; In 1,4-dioxane;

DOI:10.1246/cl.1988.857

upstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

3,4-dihydro-2H-pyran

tritylsulfenyl chloride

1-[(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-3-tritylsulfanyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

C₁₁₁H₉₆Cl₄N₆O₂₁P₂S₂

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