(+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate

Base Information

• Chemical Name: (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate
• CAS No.: 259794-49-5
• Molecular Formula: C₂₂H₂₀N₂O₅S
• Molecular Weight: 424.477

Synonyms:(+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate

Chemical Property of (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate

There total 5 articles about (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+/-)-methyl 2-{[({3-[(methoxycarbonyl)methyl]phenyl}amino)sulfonyl]amino}-3(naphthalen-2-yl)propanoate (259794-48-4) → (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ6,2,5-thiadiazolan-2-yl}phenyl)ethanoate (259794-49-5)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane; at 20 ℃; for 12h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2432::AID-HLCA2432>3.0.CO;2-H

Reference yield:

(3-amino-phenyl)-acetic acid methyl ester (52913-11-8) → (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ6,2,5-thiadiazolan-2-yl}phenyl)ethanoate (259794-49-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 1.39 g / Et₃N / CH₂Cl₂ / 6 h / 20 °C

3: 90 percent / Et₃N / acetonitrile / 12 h / Heating

4: 86 percent / t-BuLi / pentane; tetrahydrofuran / 12 h / 20 °C

With tert.-butyl lithium; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; pentane; 1: Condensation / 2: Cyclization / 3: Substitution / 4: Cyclization;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2432::AID-HLCA2432>3.0.CO;2-H

Reference yield:

(+/-)-3-(2-naphthyl)alanine methyl ester hydrochloride (123929-73-7) → (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ6,2,5-thiadiazolan-2-yl}phenyl)ethanoate (259794-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / acetonitrile / 12 h / Heating

2: 86 percent / t-BuLi / pentane; tetrahydrofuran / 12 h / 20 °C

With tert.-butyl lithium; triethylamine; In tetrahydrofuran; acetonitrile; pentane; 1: Substitution / 2: Cyclization;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2432::AID-HLCA2432>3.0.CO;2-H

upstream raw materials:

(+/-)-methyl 2-{[({3-[(methoxycarbonyl)methyl]phenyl}amino)sulfonyl]amino}-3(naphthalen-2-yl)propanoate

(3-amino-phenyl)-acetic acid methyl ester

(+/-)-3-(2-naphthyl)alanine methyl ester hydrochloride

methyl 2-(3-{[(2-oxo-1,3-oxazolan-3-yl)sulfonyl]amino}phenyl)ethanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 259794-49-5 (+/-)-methyl 2-(3-{4-[(naphthalen-2-yl)methyl]-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl}phenyl)ethanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send