tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

Base Information

Chemical Name:tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate
CAS No.:1237519-07-1
Molecular Formula:C₃₅H₃₁N₃O₄
Molecular Weight:557.649
Hs Code.:

Synonyms:tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

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Chemical Property of tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

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Technology Process of tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

There total 5 articles about tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890316-40-2
tert-butyl 2-amino-4-phenylbenzoate

: 2-(benzyloxy)-5-(pyrimidin-2-yl)benzoic acid chloride

: 1237519-07-1
tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1.33333h;

Reference yield:

: 1237517-84-8
2-(benzyloxy)-5-(pyrimidin-2-yl)benzoic acid

: 1237519-07-1
tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C

2: pyridine / dichloromethane / 1.33 h / 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 850350-09-3
phenylmethyl 5-bromo-2-[(phenylmethyl)oxy]benzoate

: 1237519-07-1
tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2.5 h / Inert atmosphere; Reflux

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 9 h / Reflux; Inert atmosphere

3.1: sodium hydroxide; water / 1,4-dioxane; methanol / 4 h / 20 °C

3.2: pH 1

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.17 h / 20 °C

5.1: pyridine / dichloromethane / 1.33 h / 20 °C

With pyridine; oxalyl dichloride; water; potassium acetate; sodium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;