2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

Base Information

Chemical Name:2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid
CAS No.:1237514-65-6
Molecular Formula:C₂₄H₁₇N₃O₄
Molecular Weight:411.417
Hs Code.:

Synonyms:2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

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Chemical Property of 2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

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Technology Process of 2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

There total 7 articles about 2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237519-08-2
tert-butyl 2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

: 1237514-65-6
2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 1237519-07-1
tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoate

: 1237514-65-6
2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate; 1,4-dioxane; methanol / 2.75 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 2-(benzyloxy)-5-(pyrimidin-2-yl)benzoic acid chloride

: 1237514-65-6
2-(2-hydroxy-5-(pyrimidin-2-yl)benzamido)-4-phenylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1.33 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; 1,4-dioxane; methanol / 2.75 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With pyridine; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;