2-Nitro-5-hydroxybenzofuran

Base Information

• Chemical Name: 2-Nitro-5-hydroxybenzofuran
• CAS No.: 40024-32-6
• Molecular Formula: C8H5NO4
• Molecular Weight: 179.13
• Mol file: 40024-32-6.mol

Synonyms:2-Nitrobenzofuran-5-ol;5-Hydroxy-2-nitro-benzofuran;5-Benzofuranol,2-nitro;2-Nitro-5-hydroxybenzofuran;5-hydroxy-2-nitrobenzofuran;

Chemical Property of 2-Nitro-5-hydroxybenzofuran

Chemical Property:

• Vapor Pressure: 1.65E-05mmHg at 25°C
• Boiling Point: 354.3°C at 760 mmHg
• Flash Point: 168.1°C
• PSA: 79.19000
• Density: 1.536g/cm³
• LogP: 2.56980
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Nitrobenzofuran-5-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Nitro-5-hydroxybenzofuran

There total 4 articles about 2-Nitro-5-hydroxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxy-5 nitro-2 benzofuranne (30335-72-9) → 5-hydroxy-2-nitrobenzofuran (40024-32-6)

Guidance literature:

With pyridine hydrochloride; at 180 ℃; for 1h;

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 5-hydroxy-2-nitrobenzofuran (40024-32-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 0.25 h / 90 °C

1.2: 3 h / 135 °C

2.1: sodium tetrahydroborate; methanol / 0 - 20 °C

3.1: tetra-(n-butyl)ammonium iodide; triethylamine; [bis(acetoxy)iodo]benzene / acetonitrile / 0.5 h / 35 °C

4.1: pyridine hydrochloride / 6 h / 180 °C

With methanol; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; ammonium acetate; pyridine hydrochloride; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine; In acetonitrile;

DOI:10.1002/anie.202106046

Reference yield:

2-(2-nitrovinyl)-4-methoxyphenol (35467-98-2) → 5-hydroxy-2-nitrobenzofuran (40024-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 0 - 20 °C

2: tetra-(n-butyl)ammonium iodide; triethylamine; [bis(acetoxy)iodo]benzene / acetonitrile / 0.5 h / 35 °C

3: pyridine hydrochloride / 6 h / 180 °C

With methanol; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; pyridine hydrochloride; tetra-(n-butyl)ammonium iodide; triethylamine; In acetonitrile;

DOI:10.1002/anie.202106046

upstream raw materials:

methoxy-5 nitro-2 benzofuranne

2-hydroxy-5-methoxybenzaldehyde

2-(2-nitrovinyl)-4-methoxyphenol

4-Methoxy-2-(2-nitro-ethyl)-phenol

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