1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole

Base Information

• Chemical Name: 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole
• CAS No.: 149071-18-1
• Molecular Formula: C₂₁H₂₄BrNO₃S
• Molecular Weight: 450.396
• Mol file: 149071-18-1.mol

Synonyms:1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole

Chemical Property of 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole

There total 4 articles about 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-isopropyl-2-(4-hydroxy-benzenesulphonyl)indole (121347-07-7) + 1,3-dibromo-propane (109-64-8) → 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole (149071-18-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1021/jm00062a015

Reference yield:

3-Isopropyl-2-(4-methoxy-phenylsulfanyl)-1H-indole → 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole (149071-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / MCPBA / CH₂Cl₂ / 2 h / Ambient temperature

2: 85 percent / 1.) NaH, HMPT / 12 h / Ambient temperature

3: 82 percent / NaH, C₂H₅SH / dimethylformamide / 7 h / 135 °C

4: K₂CO₃ / dimethylformamide / 1 h / 100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; ethanethiol; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a015

Reference yield:

3-isopropyl-2-<(4-methoxyphenyl)sulfonyl>indole (121347-01-1) → 1-methyl-3-isopropyl-2-[4-(3-bromopropoxy)benzenesulfonyl] indole (149071-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 1.) NaH, HMPT / 12 h / Ambient temperature

2: 82 percent / NaH, C₂H₅SH / dimethylformamide / 7 h / 135 °C

3: K₂CO₃ / dimethylformamide / 1 h / 100 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; potassium carbonate; ethanethiol; In N,N-dimethyl-formamide;

DOI:10.1021/jm00062a015

upstream raw materials:

1-methyl-3-isopropyl-2-(4-hydroxy-benzenesulphonyl)indole

1,3-dibromo-propane

3-isopropyl-2-<(4-methoxyphenyl)sulfonyl>indole

1-methyl-3-isopropyl-2-<(4-methoxyphenyl)sulfonyl>indole