3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Name:3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955406-96-9
Molecular Formula:C₂₂H₂₃Cl₂N₅O
Molecular Weight:444.364
Hs Code.:

Synonyms:3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 13 articles about 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 955406-09-4
trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 955406-96-9
3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h;

Reference yield:

: 911724-19-1
3-(2,6-dichloro-4-methoxy-benzyl)-1-(4-oxo-cyclohexyl)-pyrrolidin-2-one

: 955406-96-9
3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 140 °C

2.1: hydrazine / ethanol / 72 h / 20 °C

3.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C

3.2: 0.25 h / 0 °C

3.3: pH 7

4.1: pyridine / 4.08 h / 0 - 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 80 °C

With pyridine; boron tribromide; sodium carbonate; triethylamine; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 955406-96-9
3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 17 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -67 °C

2.2: 3 h / -78 °C

3.1: water; toluene-4-sulfonic acid / acetone / 24 h / 20 °C

3.2: 1 h / 45 °C

4.1: triethylamine / 140 °C

5.1: hydrazine / ethanol / 72 h / 20 °C

6.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C

6.2: 0.25 h / 0 °C

6.3: pH 7

7.1: pyridine / 4.08 h / 0 - 20 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 80 °C

With pyridine; water; boron tribromide; sodium tris(acetoxy)borohydride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; hydrazine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone;