(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

Base Information

Chemical Name:(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile
CAS No.:1415645-81-6
Molecular Formula:C₁₈H₁₂F₃N₅O
Molecular Weight:371.321
Hs Code.:

Synonyms:(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

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Chemical Property of (Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

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Technology Process of (Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

There total 4 articles about (Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 155431-49-5
1-(4-trifluoromethylphenyl)-1,4-dihydrotetrazol-5-one

: 139413-81-3
(E)-2-(bromomethyl)-3-phenylacrylonitrile

: 1415645-81-6
(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1007/s00044-012-0331-4

Reference yield:

: 19362-96-0
2-(1-hydroxybenzyl)acrylonitrile

: 1415645-81-6
(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0331-4

Reference yield:

: 100-52-7
benzaldehyde

: 1415645-81-6
(Z)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)-3-phenylacrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / 20 °C

2: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0331-4