1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone
CAS No.:953042-96-1
Molecular Formula:C₂₅H₂₄N₆O₂S₂
Molecular Weight:504.637
Hs Code.:

Synonyms:1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

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Chemical Property of 1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

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Technology Process of 1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

There total 12 articles about 1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 953046-13-4
3-phenoxy-N-(3-(piperidin-4-yl)-1,2,4-thiadiazol-5-yl)-5-(pyridin-2-ylthio)pyridin-2-amine

: 108-24-7
acetic anhydride

: 953042-96-1
1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

Guidance literature:: With triethylamine; In tetrahydrofuran; for 3h;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 953042-96-1
1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 16 - 25 °C

1.2: 24 h / 110 °C

2.1: hydrogen; sodium acetate / 10 % Pd(OH)2/C / ethanol / 18 h / 1810.07 Torr

3.1: bromine / chloroform / 1 h / 0 °C

4.1: methyllithium / tetrahydrofuran / 0.08 h / -78 °C

4.2: 0.17 h / -78 °C

5.1: pyridine / acetonitrile / 0.67 h / 40 °C

5.2: 50 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 1 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 3 h

With pyridine; hydrogenchloride; methyllithium; hydrogen; bromine; sodium acetate; sodium hydride; triethylamine; 10 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1065607-12-6
3-(2,4-dibromophenoxy)pyridin-2-amine

: 953042-96-1
1-(4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; sodium acetate / 10 % Pd(OH)2/C / ethanol / 18 h / 1810.07 Torr

2.1: bromine / chloroform / 1 h / 0 °C

3.1: methyllithium / tetrahydrofuran / 0.08 h / -78 °C

3.2: 0.17 h / -78 °C

4.1: pyridine / acetonitrile / 0.67 h / 40 °C

4.2: 50 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 1 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 3 h

With pyridine; hydrogenchloride; methyllithium; hydrogen; bromine; sodium acetate; triethylamine; 10 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; acetonitrile;