5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

Base Information

Chemical Name:5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone
CAS No.:230285-36-6
Molecular Formula:C₃₃H₄₂O₄Si
Molecular Weight:530.78
Hs Code.:

Synonyms:5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

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Technology Process of 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

There total 8 articles about 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 230285-34-4
5-(tert-butyldiphenylsiloxy)-1-hydroxy-4-methyl-1-phenyl-3-pentanone

: 110-87-2
3,4-dihydro-2H-pyran

: 230285-36-6
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃;
DOI:10.1021/jo991570o

Reference yield:

: 230285-32-2
1,5-dihydroxy-4-methyl-1-phenyl-3-pentanone

: 230285-36-6
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2: 93 percent / PPTs / CH₂Cl₂ / 20 °C

With dmap; pyridinium p-toluenesulfonate; triethylamine; In dichloromethane;
DOI:10.1021/ol990564b

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 230285-36-6
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₄

2: Acid hydrolysis

3: LDA

4: 42 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

5: 93 percent / PPTs / CH₂Cl₂ / 20 °C

With dmap; lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; triethylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ol990564b