5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

Base Information

Chemical Name:5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane
CAS No.:230285-46-8
Molecular Formula:C₃₃H₄₄O₃Si
Molecular Weight:516.796
Hs Code.:

Synonyms:5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

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Chemical Property of 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

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Technology Process of 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

There total 11 articles about 5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230285-36-6
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanone

: 230285-46-8
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / NaBH₄ / methanol / 0.5 h / 20 °C

2.1: NaH / various solvent(s); tetrahydrofuran

2.2: 92 percent / various solvent(s); tetrahydrofuran / 20 h / 20 °C

3.1: AIBN; n-Bu₃SnH / benzene / 2 h / Heating

3.2: 95 percent / NaBH₄ / methanol / 0.08 h / 20 °C

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/ol990564b

Reference yield:

: 230285-44-6
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)-3-pentanol

: 230285-46-8
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / various solvent(s); tetrahydrofuran

1.2: 92 percent / various solvent(s); tetrahydrofuran / 20 h / 20 °C

2.1: AIBN; n-Bu₃SnH / benzene / 2 h / Heating

2.2: 95 percent / NaBH₄ / methanol / 0.08 h / 20 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/ol990564b

Reference yield:

: 230285-32-2
1,5-dihydroxy-4-methyl-1-phenyl-3-pentanone

: 230285-46-8
5-(tert-butyldiphenylsiloxy)-4-methyl-1-phenyl-1-(2-tetrahydropyranyloxy)pentane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 42 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2.1: 93 percent / PPTs / CH₂Cl₂ / 20 °C

3.1: 89 percent / NaBH₄ / methanol / 0.5 h / 20 °C

4.1: NaH / various solvent(s); tetrahydrofuran

4.2: 92 percent / various solvent(s); tetrahydrofuran / 20 h / 20 °C

5.1: AIBN; n-Bu₃SnH / benzene / 2 h / Heating

5.2: 95 percent / NaBH₄ / methanol / 0.08 h / 20 °C

With dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ol990564b