4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

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Chemical Name:4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one
CAS No.:1610592-81-8
Molecular Formula:C₃₁H₃₀N₆O₄
Molecular Weight:550.617
Hs Code.:

Synonyms:4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

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Chemical Property of 4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

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Technology Process of 4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

There total 10 articles about 4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1610592-79-4
1-{6,7,9,10-tetrahydro-7-[ (triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidine-2,4(1H,3H)-dione

: 1610592-81-8
4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

Guidance literature:: 1-{6,7,9,10-tetrahydro-7-[ (triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidine-2,4(1H,3H)-dione; With 1,2,4-Triazole; triethylamine; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

With trichlorophosphate; In acetonitrile; Inert atmosphere;

With ammonium hydroxide; In 1,4-dioxane; for 2h; Inert atmosphere;
DOI:10.1002/hlca.201300289

Reference yield:

: 2-[(2,3-dihydro-7-oxo-7H-[1,3]oxazolo[3,2-a]pyrimidin-3-yl)oxy]-3-(triphenylmethoxy)propyl benzoate

: 1610592-81-8
4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / N,N-dimethyl-formamide / 5 h / 70 °C / Inert atmosphere

2.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 0.83 h / 20 °C / Inert atmosphere; Sonication

4.1: toluene / 18 h / Inert atmosphere; Reflux

5.1: triethylamine; 1,2,4-Triazole / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

5.2: Inert atmosphere

5.3: 2 h / Inert atmosphere

With 1,2,4-Triazole; sodium azide; sodium methylate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/hlca.201300289

Reference yield:

: 1610592-76-1
2-[2-azido-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)ethoxy]-3-(triphenylmethoxy)propyl benzoate

: 1610592-81-8
4-amino-1-{6,7,9,10-tetrahydro-7-[(triphenylmethoxy)methyl]-4H-[1,2,3]triazolo[5,1-f][1,4,7]dioxazonin-9-yl}pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 0.83 h / 20 °C / Inert atmosphere; Sonication

3.1: toluene / 18 h / Inert atmosphere; Reflux

4.1: triethylamine; 1,2,4-Triazole / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

4.2: Inert atmosphere

4.3: 2 h / Inert atmosphere

With 1,2,4-Triazole; sodium methylate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1002/hlca.201300289