2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

Base Information

Chemical Name:2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid
CAS No.:755030-90-1
Molecular Formula:C₂₄H₂₁N₃O₆
Molecular Weight:447.447
Hs Code.:

Synonyms:2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

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Chemical Property of 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

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Technology Process of 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

There total 9 articles about 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 755030-84-3
methyl 4-chloro-2-{[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)-2-nitrophenyl]amino}benzoate

: 755030-90-1
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pt/C / methanol / 20 °C

2: TsOH*H₂O / toluene / 48 h / Heating

3: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

4: LiOH*H₂O / methanol / Heating

With lithium hydroxide; hydrogen; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; platinum on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; 3: Suzuki coupling;
DOI:10.1021/jm070105d

Reference yield:

: 755030-82-1
methyl 2-(4-amino-3-nitrophenyl)-2-methylpropanoate

: 755030-90-1
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dppf; Cs₂CO₃ / Pd(OAc)2 / 16 h / 95 °C

2: H₂ / Pt/C / methanol / 20 °C

3: TsOH*H₂O / toluene / 48 h / Heating

4: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

5: LiOH*H₂O / methanol / Heating

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium hydroxide; hydrogen; caesium carbonate; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; platinum on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; 4: Suzuki coupling;
DOI:10.1021/jm070105d

Reference yield:

: 755030-86-5
methyl 2-{[2-amino-4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]amino}-4-chlorobenzoate

: 755030-90-1
2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH*H₂O / toluene / 48 h / Heating

2: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

3: LiOH*H₂O / methanol / Heating

With lithium hydroxide; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; In methanol; 1,2-dimethoxyethane; toluene; 2: Suzuki coupling;
DOI:10.1021/jm070105d