methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

Base Information

Chemical Name:methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate
CAS No.:755030-88-7
Molecular Formula:C₂₅H₂₃N₃O₆
Molecular Weight:461.474
Hs Code.:

Synonyms:methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

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Chemical Property of methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

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Technology Process of methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

There total 6 articles about methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 755030-87-6
methyl 2-(3-chloro-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl)-2-methylpropanoate

: 755026-96-1
2-(3-methoxy-4-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 755030-88-7
methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

Guidance literature:: With cesium fluoride; DavePhos; palladium diacetate; In methanol; 1,2-dimethoxyethane; at 70 ℃;

Reference yield:

: 755030-84-3
methyl 4-chloro-2-{[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)-2-nitrophenyl]amino}benzoate

: 755030-88-7
methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pt/C / methanol / 20 °C

2: TsOH*H₂O / toluene / 48 h / Heating

3: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

With hydrogen; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; platinum on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; 3: Suzuki coupling;
DOI:10.1021/jm070105d

Reference yield:

: 755030-82-1
methyl 2-(4-amino-3-nitrophenyl)-2-methylpropanoate

: 755030-88-7
methyl 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dppf; Cs₂CO₃ / Pd(OAc)2 / 16 h / 95 °C

2: H₂ / Pt/C / methanol / 20 °C

3: TsOH*H₂O / toluene / 48 h / Heating

4: Cy-MAP; CsF / Pd(OAc)2 / 1,2-dimethoxy-ethane; methanol / 12 h / Heating

With 1,1'-bis-(diphenylphosphino)ferrocene; hydrogen; caesium carbonate; toluene-4-sulfonic acid; cesium fluoride; palladium diacetate; platinum on activated charcoal; In methanol; 1,2-dimethoxyethane; toluene; 4: Suzuki coupling;
DOI:10.1021/jm070105d