1-[(2-naphthyl)methyl]-2,4-benzenediol

Base Information

• Chemical Name: 1-[(2-naphthyl)methyl]-2,4-benzenediol
• CAS No.: 1271736-92-5
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.297
• Mol file: 1271736-92-5.mol

Synonyms:1-[(2-naphthyl)methyl]-2,4-benzenediol

Chemical Property of 1-[(2-naphthyl)methyl]-2,4-benzenediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2-naphthyl)methyl]-2,4-benzenediol

There total 3 articles about 1-[(2-naphthyl)methyl]-2,4-benzenediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-[(2-naphthyl)methyl]-2,4-dimethoxybenzene (1271736-90-3) → 1-[(2-naphthyl)methyl]-2,4-benzenediol (1271736-92-5)

Guidance literature:

1-[(2-naphthyl)methyl]-2,4-dimethoxybenzene; With boron tribromide; In dichloromethane; at -15 - 20 ℃; for 18h;

With water; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2010.11.028

Reference yield:

2,4-dimethoxyphenylboronic acid (133730-34-4) → 1-[(2-naphthyl)methyl]-2,4-benzenediol (1271736-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium phosphate; palladium diacetate; triphenylphosphine / toluene / 16 h / 100 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 18 h / -15 - 20 °C

2.2: 20 °C

With potassium phosphate; palladium diacetate; boron tribromide; triphenylphosphine; In dichloromethane; toluene; 1.1: Suzuki coupling;

DOI:10.1016/j.ejmech.2010.11.028

Reference yield:

2-bromomethylnaphthyl bromide (939-26-4) → 1-[(2-naphthyl)methyl]-2,4-benzenediol (1271736-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium phosphate; palladium diacetate; triphenylphosphine / toluene / 16 h / 100 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 18 h / -15 - 20 °C

2.2: 20 °C

With potassium phosphate; palladium diacetate; boron tribromide; triphenylphosphine; In dichloromethane; toluene; 1.1: Suzuki coupling;

DOI:10.1016/j.ejmech.2010.11.028

upstream raw materials:

1-[(2-naphthyl)methyl]-2,4-dimethoxybenzene

2,4-dimethoxyphenylboronic acid

2-bromomethylnaphthyl bromide

Downstream raw materials:

5-[(2-naphthyl)methyl]-2-hydroxy-2,5-cyclohexadiene-1,4-dione