133730-34-4

Basic information

• Product Name: 2,4-Dimethoxybenzeneboronic acid
• Synonyms: RARECHEM AH PB 0099;AKOS BRN-0063;2,4-DIMETHOXYPHENYLBORONIC ACID;2,4-DIMETHOXYBENZENEBORONIC ACID;2,4-DIMETHOXYBENZENEBORONIC ACID,98+%;2,4-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride);2,4-Dimethoxyphenylboronic acid ,98%;2,4-Dimethoxybenzeneboronic acid,97%
• CAS NO: 133730-34-4
• Molecular Formula: C₈H₁₁BO₄
• Molecular Weight: 181.98
• EINECS: -0
• Product Categories: blocks;BoronicAcids;Substituted Boronic Acids;Boronic acids;Boronic Acid;Alkoxy;Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids and Derivatives;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organometallic Reagents
• Mol File: 133730-34-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 125-127 °C(lit.)
• Boiling Point: 361.1 °C at 760 mmHg
• Flash Point: 172.2 °C
• Appearance: white to beige or pink moist powder
• Density: 1.19 g/cm³
• Vapor Pressure: 7.61E-06mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 8.98±0.58(Predicted)
• BRN: 4744213
• CAS DataBase Reference: 2,4-Dimethoxybenzeneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxybenzeneboronic acid(133730-34-4)
• EPA Substance Registry System: 2,4-Dimethoxybenzeneboronic acid(133730-34-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36/37-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 133730-34-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 133730-34-4 differently. You can refer to the following data:
1. 2,4-Dimethoxyphenylboronic acid can be used:?? As a reactant in meatal-catalyzed Suzuki?Miyaura cross-coupling reaction.?? To prepare hydroxy(trimethoxy)phenanthrene by cross-coupling with bromo(benzyloxy)methoxybenzaldehyde followed by condensation and debenzylation reaction.??To synthesize 2,4-dimethoxy-1-(trifluoromethyl)benzene via Cu-catalyzed trifluoromethylation reaction.
2. Reactant for:??Suzuki-Miyaura?and Negishi couplings.
3. suzuki reaction
4. 2,4-Dimethoxyphenylboronic acid can be used: As a reactant in meatal-catalyzed Suzuki?Miyaura cross-coupling reaction. To prepare hydroxy(trimethoxy)phenanthrene by cross-coupling with bromo(benzyloxy)methoxybenzaldehyde followed by condensation and debenzylation reaction. To synthesize 2,4-dimethoxy-1-(trifluoromethyl)benzene via Cu-catalyzed trifluoromethylation reaction.

Chemical Properties

white to beige or pink moist powder

InChI:InChI=1/C8H11BO4/c1-12-6-3-4-7(9(10)11)8(5-6)13-2/h3-5,10-11H,1-2H3

Upstream product

• 1033691-64-3 C₈H₉BF₃O₂^(1-) 
• 67-56-1 methanol 
• 55124-35-1 diisopropylamine borane 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 5419-55-6 Triisopropyl borate 
• 688-74-4 boric acid tributyl ester 
• 138109-49-6 2,4-dimethoxyphenylmagnesium bromide 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 108474-22-2 2',4'-dimethoxy-biphenyl-4-carboxylic acid 
• 905267-56-3 8-(benzyloxy)-5-(2,4-dimethoxyphenyl)quinoline 
• 521267-99-2 (2S)-1-({2-[5-(2,4-Dimethoxy-phenyl)-pyridin-2-ylamino]-1,1-dimethyl-ethylamino}-acetyl)-pyrrolidine-2-carbonitrile 
• 178055-99-7 1-(2',4'-dimethoxylbiphenyl-4-yl)ethanone 
• 1021540-42-0 9,10-bis(2,4-dimethoxyphenyl)anthracene 
• 355834-36-5 [N-(1-ethyl)propyl]-5-(2,4-dimethoxyphenyl)-3,6-dimethylpyrazine-2-amine 
• 1141898-17-0 2,4,4',6',4'',6'',2''',4'''-octamethoxy-1,1':3',1'':3'',1'''-quaterphenyl 
• 107156-68-3 2,4,4',6',2',2'',4''-hexamethoxy-1,1':3',1''-terphenyl 
• 36098-18-7 1-(2,4-dimethoxyphenyl)-1H-benzo[d]imidazole 
• 1192014-98-4 1-(2,4-dimethoxyphenyl)-2-methyl-1H-imidazole 
• 98528-35-9 2-(2,4-dimethoxyphenyl)-4,6-dimethoxybenzo[b]furan 
• 1224437-53-9 2-(2,4-dimethoxyphenyl)pyrimidine 
• 1220707-88-9 phenyl 1-(2,4-dimethoxyphenyl)-4-(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1160684-56-9 N-({2-[2,4-bis(methyloxy)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine 

Relevant articles and documents

Magnesium promoted autocatalytic dehydrogenation of amine borane complexes: A reliable, non-cryogenic, scalable access to boronic acids

Owing to the unusual reactivity of dialkylamine-borane complexes, a methodology was developed to simply access boronic acids. The intrinsic instability of magnesium aminoborohydride was tweaked into a tandem dehydrogenation borylation sequence. Proceeding via an autocatalytic cycle, amineborane dehydrogenation was induced by a variety of Grignard reagents. Overall, addition of the organomagnesium species onto specially designed dialkylamine-borane complexes led to a variety of boronic acids in high yields. In addition, the reaction can be performed under Barbier conditions, on a large scale.

ANTI-TRICHOPHYTIC ADHESIVE PATCH

According to the present invention, a patch for nail and/or skin having antifungal activity against dermatophytes, and having higher nail permeability can be provided. The patch for nail and/or skin for prevention or treatment of dermatophytosis comprises in a pressure sensitive adhesive layer a compound represented by the formula: wherein R1 represents a hydrogen atom, C1-6 alkyl, or trifluoromethyl; R2 represents a hydrogen atom, C1-6 alkyl, halogen, -COO(C1-6 alkyl), or (CH2)1-3COOR (R represents a hydrogen atom or C1-6 alkyl); R3 represents a hydrogen atom, C1-6 alkyl, amino, trifluoromethyl, or OR (R represents a hydrogen atom or C1-6 alkyl); R4 represents a hydroxyl group; R5 represents a hydrogen atom, C1-6 alkyl, a hydroxyl group, or halogen; R6 represents a hydrogen atom, C1-6 alkyl, trifluoromethyl, halogen, amino, -NRaRb, nitro, hydroxy-C1-6 alkyl, -CONRaRb, -COO(C1-6 alkyl), -COOH, -(CH2)1-3COOR, or ORa (R represents a hydrogen atom or C1-6 alkyl, Ra and Rb may be the same or different from each other, and each represent a hydrogen atom, C1-6 alkyl, or C1-6 acyl); R7 represents a hydrogen atom, C1-6 alkyl, -OR (R represents a hydrogen atom or C1-6 alkyl), or halogen; and R8 represents a hydrogen atom, C1-6 alkyl, a hydroxyl group, amino, or nitro, or a salt thereof.

TOPICAL LIQUID AGENT FOR THE TREATMENT OF DERMATOPHYTOSIS

A topical liquid agent for a nail and/or skin for prevention or treatment of dermatophytosis comprises a film-forming agent and a compound represented by the formula: wherein R1 represents hydrogen, C1-6 alkyl, or trifluoromethyl, R2 represents hydrogen, C1-6 alkyl, halogen, —COO(C1-6 alkyl), or (CH2)1-3COOR where R represents hydrogen or C1-6 alkyl, R3 represents hydrogen, C1-6 alkyl, amino, trifluoromethyl, or OR where R represents hydrogen or C1-6 alkyl, R4 represents hydroxyl, R5 represents hydrogen, C1-6 alkyl, hydroxyl, or halogen, R6 represents hydrogen, C1-6 alkyl, trifluoromethyl, halogen, amino, —NRaRb, nitro, hydroxy-C1-6 alkyl, —CONRaRb, —COO(C1-6 alkyl), —COOH, —(CH2)1-3COOR, or ORa where R represents hydrogen or C1-6 alkyl, Ra and Rb each represent hydrogen, C1-6 alkyl, or C1-6 acyl, R7 represents hydrogen, C1-6 alkyl, —OR where R represents hydrogen or C1-6 alkyl, or halogen, R8 represents hydrogen, C1-6 alkyl, hydroxyl, amino, or nitro, or a salt thereof.