1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 88205-36-1
• Molecular Formula: C₂₃H₃₀N₂O₅
• Molecular Weight: 414.502
• Mol file: 88205-36-1.mol

Synonyms:1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)isoquinolinium methyl sulphate (88215-25-2) → 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline (88205-36-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 1h; Heating;

DOI:10.1039/P19830002059

Reference yield: 85.0%

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2-dihydroisoquinoline (88205-35-0) → 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline (88205-36-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 48h; under 12928.7 Torr;

DOI:10.1039/P19830002059

Reference yield:

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)isoquinolinium iodide (88205-39-4) → 1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2,3,4-tetrahydroisoquinoline (88205-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / sodium borohydride / ethanol / 0.5 h / Ambient temperature

2: 85 percent / H₂ / platinum oxide / ethyl acetate / 48 h / 12928.7 Torr

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In ethanol; ethyl acetate;

DOI:10.1039/P19830002059

upstream raw materials:

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)-1,2-dihydroisoquinoline

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)isoquinolinium methyl sulphate

2-acetamido-1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

methyl iodide

Downstream raw materials:

2-acetamido-6,7-dimethoxy-1-(3',4'-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolinium iodide

(3,4-dimethoxyphenyl)methanol

3,4-dimethoxy-benzaldehyde