Technology Process of (2S,3S)-4-(4-methoxybenzyloxy)-3-methylbutane-1,2,3-triol
There total 4 articles about (2S,3S)-4-(4-methoxybenzyloxy)-3-methylbutane-1,2,3-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3S)-ethyl 2,3-dihydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate;
With
lithium borohydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
Inert atmosphere;
DOI:10.1016/j.tetlet.2012.03.071
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 20 h / 0 - 20 °C / Inert atmosphere
2.1: AD-mix-α; methanesulfonamide / water; tert-butyl alcohol / 72 h / -1 °C
3.1: lithium borohydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.2: Inert atmosphere
With
lithium borohydride; methanesulfonamide; AD-mix-α; sodium hydride;
In
tetrahydrofuran; water; tert-butyl alcohol;
1.2: Horner-Wadsworth-Emmons olefination / 2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tetlet.2012.03.071
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium oxide; methyl trifluoromethanesulfonate / 4-methyl-1,2,3-trifluorobenzene / 12 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 20 h / 0 - 20 °C / Inert atmosphere
3.1: AD-mix-α; methanesulfonamide / water; tert-butyl alcohol / 72 h / -1 °C
4.1: lithium borohydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.2: Inert atmosphere
With
lithium borohydride; methanesulfonamide; AD-mix-α; magnesium oxide; sodium hydride; methyl trifluoromethanesulfonate;
In
tetrahydrofuran; water; 4-methyl-1,2,3-trifluorobenzene; tert-butyl alcohol;
2.2: Horner-Wadsworth-Emmons olefination / 3.1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tetlet.2012.03.071
